Mubi dropped the first official trailer for its film The Substance, starring Demi Moore, Dennis Quaid, and Margaret Qualley in key roles. Coralie Fargeat directed the film from her own script, which won Best Screenplay at the 2024 Cannes Film Festival.

The trailer shows Moore as an actor or model who is trying to get work but is shunned due to her age. She then decides to take a serum-like liquid called The Substance to look young and "perfect". She has to live 7 days as her younger self while living 7 days as her older self. However, things seem to get out of control when she misuses the serum.

The official logline reads thus: “With The Substance, you can generate another you: younger, more beautiful, more perfect. You just have to share time -- one week for one, one week for the other. A perfect balance of seven days each... Easy right? If you respect the balance... What could possibly go wrong?”

The Substance also stars Hugo Diego Garcia, Gore Abrams, Matthew Geczy, Daniel Knight, Tom Morton, Tiffany Hofstetter, and Olivier Raynal.

Fargeat also produced the film with Working Title Films’ Eric Fellner and Tim Bevan.

On the technical front, it has editing by Fargeat, Jérôme Eltabet, and Valentin Feron; music by Raffertie; and cinematography by Benjamin Kracun. The Substance is all set to hit theatres on September 20.