Seven months after closing Only Murders in the Building season 5, Hulu has announced production on the sixth season in London with a selfie showing the main characters Charles Haden Savage (Steve Martin), Oliver Putnam (Martin Short) and Mabel Mora (Selena Gomez) returning along with Detective Donna Williams (Da'Vine Joy Randolph). Co-creator and screenwriter John Hoffman posted the selfie which also shows the crew in the backdrop setting the stage for the upcoming season.

Season 5 revolved around Charles, Oliver and Mabel investigating the death of Arconia's beloved doorman, Lester (Teddy Coluca) and finding a secret gambling centre in the basement of their apartment. They discover that a clandestine group of billionaires is vying to build New York City’s first legal casino in the Arconia.

While zeroing in on the trio for killing Lester, they eventually find that Mayor Beau Tillman was behind the murder. In the final cliffhanger, the series ends with the murder-mystery-solving-podcasters finding Cinda Canning (Tina Fey), whose podcast they first began hearing together, dead just outside the Arconia, teasing her demise as the mystery for the next season. Her death is linked to a mysterious case in London.

While season 6 is also confirmed to have 10 episodes, the extended cast and a tentative release date is yet to be announced.

Apart from the three podcasters-cum-investigators, season 5 featured returning members Meryl Streep, Michael Cyril Creighton, Richard Kind and Nathan Lane. Newcomers for the season were are Bobby Cannavale, Renée Zellweger, Logan Lerman, Christoph Waltz, Téa Leoni, Keegan-Michael Key, Beanie Feldstein, Dianne Wiest and Jermaine Fowler.