Morena Baccarin and Stefan Kapicic will reprise their roles as Vanessa and Colossus in the upcoming sequel Deadpool 3. In the first Deadpool film, Vanessa was Wade Wilson's (Ryan Reynolds) fiancée. A big part of the plot of 2018's Deadpool 2 was Wade grieving over Vanessa's death at the beginning of the film, though he managed to bring her back in the end. Outside of Marvel, Baccarin has also appeared in the DC Universe. She played Leslie Thompkins in Fox's Batman prequel Gotham and voiced the computer Gideon in The CW's The Flash.

Kapicic played the X-Men character Colossus in both films. In the films, Colossus wants Deadpool to join the X-Men and become a hero. 

Hugh Jackman will reprise his role as Wolverine/Logan. Jackman and Reynolds previously appeared together in 2009's X-Men Origins: Wolverine. Archived footage of Jackman from the film was also used for a post-credit scene in Deadpool 2. Jackman had previously retired from the role after 2017's Logan before signing on to return for Deadpool 3.

Deadpool 3 is scheduled to be released on November 8, 2024.